Search results for " unit operations"
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Unifying Continuous Biomanufacturing Operations
Concludes Bonham-Carter, there are “new product opportunities in nearly all unit operations, given there are no drugs commercially produced in a continuous downstream process yet.”
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Technology solutions simplifying chromatography unit operations
Chromatography operations typically involve steps such as resin slurry preparation, column packing, cleaning, unpacking, and resin storage. While each of the aforementioned steps can potentially be …
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Continuous Processing for the Production of Biopharmaceuticals
While a bulk of the research efforts thus far have been focused on making individual unit operations continuous, a few studies have explored the possibility of a continuous end-to-end biomanufacturing…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
The ultimate goal, according to Gravallese, is optimizing the facility around unit operations so they can be segregated where open processing cannot be avoided and staggered changeovers are possible. …
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Continuous Manufacturing: A Changing Processing Paradigm
…w process cycle times; reduced operating costs; increased flexibility; elimination of hold tanks and unit operations that do not provide value; high equipment utilization rates; high volumetric produ…
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Modular Manufacturing Platforms for Biologics
They can also include configurable skids; process modules/skids based on single-use equipment; or unit operations within modules, such as suites made exclusively for aseptic filling of prefilled syrin…
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Determining Criticality, Part Two: DoE and Data-Driven Criticality
Design spaces can be developed for each unit operation or across several or all unit operations. Although it may be simpler to develop for each unit operation, downstream unit operations may need to b…
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Technology Innovations Improve Process Chromatography Performance
“It doesn’t help that there’s approximately 30% more effort, such as resources, materials, and equipment, as harvest material goes through downstream purification due to multiple unit operations. Any …
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Digitalization: The Route to Biopharma 4.0
Implementation of these approaches requires setting up reliable communication protocols and user-friendly interfaces between the unit operations with a robust supervisory control and data acquisition …
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Selecting a Comprehensive Bioburden Reduction Plan
…e of biologics requires operators trained in aseptic techniques, with specific training for relevant unit operations and cleanroom classification. Operators in the critical final fill area require tr…